Concordance of Near-Infrared Autofluorescence in Parathyroid Glands with Definitive Histopathology Result
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Abstract
Introduction: Hypoparathyroidism is the most frequent complication of thyroidectomy, which is influenced by multiple factors, mainly unintentional resection, due to its location, size and difficulty in identification, leading to post-surgical hypocalcemia in 20 to 30% of which 1 to 3% of cases, hypocalcemia may be permanent; due to this techniques have been described for its identification, Benmiloud et al. conducted a case-control study where they compared the efficacy of near-infrared light in detecting parathyroid glands. Parathyroid identification rates were higher in the near-infrared light group compared to the control group (76.3% vs 65.7%).
Material and Methods: Cross-sectional, prospective, comparative and analytical study in a third-level hospital in Mexico City, in 20 patients diagnosed with primary and secondary hyperparathyroidism undergoing partial or total parathyroid surgery, with the aim of determining the concordance of near-infrared autofluorescence in these glands and the resultatwhich final histopathological, statistical analysis was performed in SPSS 24, with the Kappa and ji-square coefficient,
Results:A total of 20 patients undergoing parathyroid surgery, the most common histopathological finding with 44.2% was parathyroid hyperplasia, with a sensitivity for autofluorescence with the result of histopathology of 82.4% and specificity of 88.9% with PPV of 93.3% and NPV 72.7% and a Kappa coefficient with a value of 0.67 with a p <0.005.
Conclusions: The concordance of near-infrared autofluorescence in parathyroid glands with the result of histopathology is considerable, with a good overall performance for timely detection of parathyroid tissue
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