Salmon DNA Combination for Hypertrohic Scar Treatment with Diabetes Mellitus Type 2: A Case Report
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Abstract
Background: Hypertrophic scar is a problem of wound healing process. Salmon DNA (Polydeoxyribonucleotide/PDRN) is a mixture of deoxyribonucleotide gonads derivate of Oncorhynchus mykiss (Rainbow Salmon) that helps wound healing process and preventing the formation of scars.
Methods: A diabetic 30-year-old man with 5x3 cm hypertrophic scar on his dorsal hand since 10 months. The hypertrophic scar had been treated with ointments and Triamcinolone 10mg/ml every 2 weeks for 2 months. The patient was treated with intradermal injection 2% Polydeoxyribonucleotide (PDRN) in 2.7 ml (PDRN Bellavita®) and topical therapy containing Allium cepa extract and Vitamin E (Lanakeloid®) every 12 hours. PDRN was injected intradermal into the whole area of the scar using a 30-G Needle at a dose of 0.05 ml at each injection site with a distance of about 0.5-1.0 cm. PDRN was given every 2 weeks for 3 months. Vancouver Scar Scale was used to asses hypertrophic scar treatment progress.
Results: The Vancouver Scar Scale was downgrading from 10 to 3 in 3 months.
Conclusion: The combination of PDRN injection with topical administration of Allium cepa and vitamin E, is effective for hypertrophic scar treatment.
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